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Compositions:
Aqua/Water, Cetearyl , Alcohol, Deceth,
Propylene Glycol, Laureth, Oleth-30,
Ammonium Hydroxide,
Lauric Acid, Hexadimethrine Chloride,
Glycol Distarate, Resorcinol, ethanol.
Indications:
Controls hair fall.
Descriptions:
The present work was undertaken to study
in hairdressers exposed to several
irritants and allergens (prevalently
hair-dyeing) and affected by hand
contact dermatitis the possible
correlation between exposure and
direct-oxidative DNA damage, production
of tumour necrosis factor alpha (TNFα)
and allergic inflammatory disease. We
evaluated in 19 hairdressers with hand
contact dermatitis, 14 allergic contact
dermatitis (ACD) and 5 irritant contact
dermatitis (ICD) and in a selected
control group TNFα serum levels by ELISA
and direct-oxidative DNA damage by Fpg (formamido-pyrimidine-glycosylase)-modified
Comet test on blood. Hairdressers were
divided on the basis of number of
hair-dyeing carried out weekly into 2
groups: low-exposure (<60
hair-dyeing/week) and high-exposure
hairdressers (≥60 hair-dyeing/week) that
reflect also the exposure to other
allergens and irritants and 2 different
tasks (hairdressers and apprentice
hairdressers, respectively).
Serum levels of TNFα in hairdressers
with ACD were significantly higher than
controls with a correlation to exposure
level. Significant DNA damage in ICD
hairdressers with higher exposure as
compared to controls was found. These
findings suggest that occupational
exposure can induce in hairdressers,
particularly ICD, DNA damage, increase
the TNFa levels particularly in ACD and
induce allergic sensitization,
suggesting a relationship between
direct-oxidative DNA damage, TNFα
production and allergic inflammatory
disease.
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Quality
